ACROBiosystems – Immune Checkpoint Proteins

免疫檢查點蛋白質 

免疫檢查點蛋白包括參與免疫檢查點路徑的共激蛋白質與抑制蛋白質。共激受體會在遭遇病原體時發出促進免疫反應的信號,相對地,抑制受體為了避免過度發炎,會發出抑制T細胞活性的抑制信號。近年來,免疫檢查點蛋白因為跟癌症治療相關的研究而備受注目。根據研究,腫瘤細胞為了迴避免疫系統的攻擊,會劫持免疫檢查點途徑,利用抑制蛋白質的機制來保護自己。因此,有許多研究者認為將被腫瘤細胞利用的檢查點無效化,並重建體內的免疫系統能有助於治療癌症。有趣的是,目前的研究已經證明對應兩個免疫檢查點蛋白的抗體――抗CTLA4與抗PD1單株抗體,對惡性腫瘤患者投以實驗後,呈現出具有抗腫瘤的功效。基於這些成果,研究者正在積極擴大研究其他免疫檢查點蛋白,以找到更多治療癌症的新方法。Acrobiosystems公司為了支援這些研究者的研究,開發了一系列的免疫檢查點蛋白,涵蓋了大多數已知的免疫檢查點蛋白質。這些蛋白質都有經過嚴格的檢驗,一貫維持優良的品質供作實驗。

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包含多樣不同種類的檢查點蛋白質

Acrobiosystems有製造多種免疫檢查點蛋白質。客戶可以選擇不同標識(如Fc, His, Strep)或者無標識的蛋白產品。除了常用的人種屬之外,還有提供動物實驗用的小鼠、大鼠、兔、恒河猴(rhesus macaque)和食蟹猴(cynomolgus)的免疫檢查點蛋白質。

 

高品質蛋白質

純度與生物活性的一致性是製造高品質重組蛋白質不可缺的要素。Acrobisystems公司所有的蛋白質都有經過嚴格的純化手續跟生物活性檢測。有接受過得檢驗與符合的品質如下所示:
●蛋白質純度90%以上 (SDS-PAGE、SEC-HPLC)
●生物活性檢測 (functional ELISA)
●內毒素(endotoxin)含量 1EU/ug以下 (LAL法)

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Human PD-L1 (Cat#PD1-H5229)的純度(SEC-HPLC、SDS-PAGE)

 

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Human PD-L1 (Cat#PD1-H5229)的PDL1 (Cat#PD1-H5258)對應的生物活性

生物素(biotin)化標識蛋白質與重度生物素化標識(heavy-labeled)蛋白質

生物素化標識能簡便地開發出檢測方式。ACROBiosystems公司有提供多種ready-to-use的生物素化標識檢查點蛋白質。這些蛋白質都經由ACROBiosystems獨家的生物素化標識、具備高度的生物活性、並且在不同批次間維持變化極微的一致性。此外,還有提供可以應用於質量分析的重度生物素化標識(heavy-labeled)蛋白質。

抑制分子檢測套組(inhibitor screening kit)

AcroBiosystems公司有販售針對PD1-PD-L-1的抑制分子檢測套組(產品編號:EP-101)。能夠迅速、高通量篩檢出PD1路徑中的抑制分子抗體跟小分子。

產品列表 (關於本產品的其他資料,請下載Excel產品列表檔案作進一步的參考)

4-1BB
41B-H8258 Biotinylated Human 4-1BB / TNFRSF9, Fc Tag, ultra sensitivity (primary amine labeling)
41B-H5227 Human 4-1BB / TNFRSF9 Protein
41B-H5258 Human 4-1BB / TNFRSF9 Protein, Fc Tag
41B-M52H7 Mouse 4-1BB / TNFRSF9 Protein
41B-M5258 Mouse 4-1BB /TNFRSF9 Protein, Fc Tag
4-1BB Ligand
41L-H5257 Human 4-1BB Ligand / TNFSF9 Protein, Fc Tag
41L-M5257 Mouse 4-1BB Ligand / TNFSF9 Protein, Fc Tag
CD80
CD0-C52H3 Cynomolgus B7-1 / CD80 Protein (HPLC-verified)
B71-H5259 Human B7-1 / CD80 Protein, Fc Tag (HPLC-verified)
B71-H5228 Human B7-1 / CD80 Protein
CD0-M5259 Mouse B7-1 / CD80 Protein, Fc Tag
CD0-C5252 Cynomolgus B7-1 / CD80 Protein, Fc Tag
CD86
CD6-C52H5 Cynomolgus B7-2 / CD86 Protein (HPLC-verified)
CD6-H5257 Human B7-2 / CD86 Protein, Fc Tag
CD6-H5223 Human B7-2 / CD86 Protein
CD6-M5251 Mouse B7-2 / CD86 Protein, Fc Tag
CD6-M52H0 Mouse B7-2 / CD86 Protein
CD6-C5254 Cynomolgus B7-2 / CD86 Protein, Fc Tag
B7H4
B74-H5222 Human B7-H4 Protein
B74-H8222 Biotinylated Human B7-H4, ultra sensitivity (primary amine labeling)
BTLA
BTA-H52E0 Human BTLA Protein
BTA-H5255 Human BTLA (31-134) Protein, Fc Tag
BTA-H5256 Human BTLA (31-150) Protein, Fc Tag
BTA-M52E2 Mouse BTLA Protein
BTA-M5253 Mouse BTLA Protein, Fc Tag
VISTA
B75-H52H0 Human B7-H5 / Gi24 / VISTA Protein
B75-H82E1 Biotinylated Human B7-H5 / Gi24 / VISTA, Avi Tag (Avitag™)
B75-H5259 Human B7-H5 / Gi24 / VISTA Protein, Fc Tag
CD27
CD7-H5254 Human CD27 / TNFRSF7 Protein, Fc Tag
CD70
TN7-H526x Human CD27 Ligand / CD70 Protein, Fc Tag
CD28
CD8-H5257 Human CD28 Protein, Fc Tag
CD8-M5257 Mouse CD28 Protein, Fc Tag
CD8-M52H6 Mouse CD28 Protein
CD40
CD0-H5253 Human CD40 / TNFRSF5 Protein, Fc Tag (HPLC-verified)
CD0-H5228 Human CD40 / TNFRSF5 Protein
CD0-C5259 Rhesus macaque CD40 / TNFRSF5 Protein, Fc Tag
CD0-C52H7 Rhesus macaque CD40 / TNFRSF5 Protein
CD0-H82F2 Biotinylated Human CD40 / TNFRSF5, His Tag & Fc Tag, Avi Tag (Avitag™)
TN5-M5259 Mouse CD40 / TNFRSF5 Protein, Fc Tag
TN5-M52H8 Mouse CD40 / TNFRSF5 Protein
CD0-C52H6 Cynomolgus CD40 / TNFRSF5 Protein
CD0-C5257 Cynomolgus CD40 / TNFRSF5 Protein, Fc Tag
CD40 Ligand
CDL-H5140 Human CD40 Ligand / TNFSF5 Protein
CDL-M5248 Mouse CD40 Ligand / TNFSF5 Protein
CTLA-4
CT4-H5229 Human CTLA-4 / CD152 Protein
CT4-H9229 Human CTLA-4 / CD152 Protein, C13 and N15-labeled
CT4-H5255 Human CTLA-4 / CD152 Protein, Fc Tag
CT4-C5256 Cynomolgus CTLA-4 Protein, Fc Tag
CT4-C5227 Cynomolgus CTLA-4 Protein
CT4-H5284 Human CTLA-4 / CD152 Protein, Strep Tag
CT4-C82E5 Biotinylated Cynomolgus CTLA-4, Avi Tag (Avitag™)
CT4-H82E4 Biotinylated Human CTLA-4, Avi Tag (Avitag™)
CT4-H82F3 Biotinylated Human CTLA-4, Fc Tag, Avi Tag (Avitag™)
CT4-R5259 Rat CTLA-4 / CD152 Protein, Fc Tag
CT4-R5250 Rabbit CTLA-4 / CD152 Protein, Fc Tag
CT4-H52A4 Human CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin
CT4-M52H5 Mouse CTLA-4 / CD152 Protein
CT4-M5256 Mouse CTLA-4 / CD152 Protein, Fc Tag
DNAM-1
DN1-H52H6 Human DNAM-1 / CD226 Protein
DN1-H5257 Human DNAM-1 / CD226 Protein, Fc Tag
GITR
GIR-R5253 Rat GITR / TNFRSF18 Protein, Fc Tag
GIR-H5228 Human GITR / TNFRSF18 Protein
GIR-R5222 Rat GITR / TNFRSF18 Protein
GIR-M5220 Mouse GITR / TNFRSF18 Protein
GIR-M5251 Mouse GITR / TNFRSF18 Protein, Fc Tag
GITR Ligand
GIL-H526a Human GITR Ligand / TNFSF18 Protein, Fc Tag
HVEM
HVM-H5258 Human HVEM / TNFRSF14 Protein, Fc Tag
HVM-H5283 Human HVEM / TNFRSF14 Protein, Strep Tag
HVM-H52E9 Human HVEM / TNFRSF14 Protein
HV4-H82F1 Biotinylated Human HVEM / TNFRSF14, Fc Tag, Avi Tag (Avitag™)
ICOS
ICS-H5250 Human ICOS / CD278 Protein, Fc Tag
LAG-3
LA3-M52H5 Mouse LAG-3 / CD223 Protein
LA3-H5222 Human LAG-3 / CD223 Protein
LA3-R52H5 Rat LAG3 /CD223 Protein
OX40
OX0-H5255 Human OX40 / TNFRSF4 / CD134 Protein, Fc Tag
OX0-H5224 Human OX40 / TNFRSF4 / CD134 Protein
OX0-C5220 Rhesus macaque OX40 / TNFRSF4 / CD134 Protein
OX0-C5251 Rhesus macaque OX40 / TNFRSF4 / CD134 Protein, Fc Tag
OX0-M5228 Mouse OX40 / TNFRSF4 / CD134 Protein
OX0-M5259 Mouse OX40 / TNFRSF4 / CD134 Protein, Fc Tag
OX0-H82F7 Biotinylated Human OX40, Fc Tag, Avi Tag (Avitag™)
OX40 Ligand
OXL-M526x Mouse OX40 Ligand / TNFSF4 Protein, Fc Tag
OXL-H52Q8 Human OX40 Ligand / TNFSF4 Protein (HPLC-verified)
OXL-H526x Human OX40 Ligand / TNFSF4 Protein, Fc Tag
PD-1
PD1-M8259 Biotinylated Mouse PD-1 / PDCD1, Fc Tag, ultra sensitivity (primary amine labeling)
PD1-H5221 Human PD-1 / PDCD1 Protein (HPLC-verified)
PD1-H5257 Human PD-1 / PDCD1 Protein, Fc Tag (HPLC-verified), low endotoxin
PD1-R52H0 Rabbit PD-1 / PDCD1 Protein
PD1-C5223 Cynomolgus PD-1 / PDCD1 Protein
PD1-C5254 Cynomolgus PD-1 / PDCD1 Protein, Fc Tag
PD1-M5228 Mouse PD-1 / PDCD1 Protein
PD1-HC214 Human PD-1 / PDCD1 Protein, Tag Free, Full Length
PD1-M5259 Mouse PD-1 / PDCD1 Protein, Fc Tag
PD1-M82F4 Biotinylated Mouse PD-1 / PDCD1, Fc Tag, Avi Tag (Avitag™)
PD1-HF257 FITC-Labeled Human PD-1 / PDCD1 Protein, Fc Tag
PD1-H82F2 Biotinylated Human PD-1 / PDCD1, His Tag & Fc Tag, Avi Tag (Avitag™)
PD1-H5284 Human PD-1 / PDCD1 Protein, Strep Tag
PD1-H9221 Human PD-1 / PDCD1 Protein, C13 and N15-labeled
PD1-R52H2 Rat PD-1 / PDCD1 Protein
PD1-RB5251 Rabbit PD-1 / PDCD1 Protein, Fc Tag
PD1-R5253 Rat PD-1 / PDCD1 Protein, Fc Tag
PD1-H82E4 Biotinylated Human PD-1 / PDCD1 (recommended for biopanning), Avi Tag (Avitag™)
PD-L1
PD1-C52H4 Cynomolgus PD-L1 / B7-H1 Protein
PD1-H5229 Human PD-L1 / B7-H1 Protein (HPLC-verified)
PD1-H5258 Human PD-L1 / B7-H1 Protein, Fc Tag, low endotoxin
PD1-H5282 Human PD-L1 / B7-H1 Protein, Strep Tag
PD1-M52A2 Mouse PD-L1 / B7-H1 Protein, mouse IgG2a Fc Tag, low endotoxin
PD1-H52A3 Human PD-L1 / B7-H1 Protein, mouse IgG1 Fc Tag, low endotoxin (HPLC-verified)
PD1-H9229 Human PD-L1 / B7-H1 Protein, C13 and N15-labeled
PD1-C5253 Cynomolgus PD-L1 / B7-H1 Protein, Fc Tag
PD1-H82F3 Biotinylated Human PD-L1 / B7-H1, His Tag & Fc Tag, Avi Tag (Avitag™)
PD1-M82F5 Biotinylated Mouse PD-L1 / B7-H1, Fc Tag, Avi Tag (Avitag™)
PD1-M5251 Mouse PD-L1 / B7-H1 Protein, Fc Tag
PD1-M5220 Mouse PD-L1 / B7-H1 Protein
PD1-H82E5 Biotinylated Human PD-L1 / B7-H1 (recommended for biopanning), Avi Tag (Avitag™)
PD-L2
PD2-H5220 Human PD-L2 / B7-DC Protein
PD2-H5251 Human PD-L2 / B7-DC Protein, Fc Tag (HPLC-verified)
PD2-H82E8 Biotinylated Human PD-L2 / B7-DC Protein (recommended for biopanning), Avi Tag (Avitag™)
PD2-M52E3 Mouse PD-L2 / B7-DC Protein
PD2-H82F6 Biotinylated Human PD-L2 / B7-DC, Fc Tag, Avi Tag (Avitag™)
PD2-H52A5 Human PD-L2 / B7-DC Protein, mouse IgG1 Fc Tag
PD2-M5254 Mouse PD-L2 / B7-DC Protein, Fc Tag
SIRP alpha
SIA-H5251 Human SIRP alpha / CD172a Protein, Fc Tag (HPLC-verified)
SIA-H52A8 Human SIRP alpha / CD172a Protein, mouse IgG1 Fc Tag (HPLC-verified)
SIA-H5351 Human SIRP alpha / CD172a Protein, Fc Tag (HPLC-verified)
SIA-H5225 Human SIRP alpha / CD172a Protein (HPLC-verified)
TIGIT
TIT-M5257 Mouse TIGIT Protein, Fc Tag
TIT-H52H3 Human TIGIT Protein
TIT-H82F1 Biotinylated Human TIGIT Protein, Fc Tag, Avi Tag (Avitag™)
TIT-H5254 Human TIGIT Protein, Fc Tag
TIT-M52E6 Mouse TIGIT Protein
TIT-C5254 Cynomolgus TIGIT Protein, Fc Tag
TIT-C5223 Cynomolgus TIGIT Protein
TIT-H82E5 Biotinylated Human TIGIT Protein, Avi Tag (Avitag™)
TIM-3
KI3-H5252 Human TIM-3 / HAVCR2 (22-142) Protein, Fc Tag
TM3-H5229 Human TIM-3 / HAVCR2 Protein
TM3-H5258 Human TIM-3 / HAVCR2 (22-200) Protein, Fc Tag
TI3-H5285 Human TIM-3 / HAVCR2 (22-200) Protein, Strep Tag
TI3-M52H1 Mouse TIM-3 / HAVCR2 Protein
TI3-M5252 Mouse TIM-3 / HAVCR2 Protein, Fc Tag
2B4
2B4-H5255 Human 2B4 / CD244 / SLAMF4 Protein, Fc Tag
2B4-H5224 Human 2B4 / CD244 / SLAMF4 Protein
B7-H2
B72-H5221 Human B7-H2 / ICOSLG Protein
CD155
CD5-H5223 Human CD155 / PVR Protein
CD5-H5251 Human CD155 / PVR Protein, Fc Tag
CD160
BY5-H5229 Human CD160 Protein
CD47
CD7-H82F6 Biotinylated Human CD47, Fc Tag, Avi Tag (Avitag™)
CD7-H5256 Human CD47 Protein, Fc Tag (HPLC-verified)
CD7-H5227 Human CD47 Protein
CD7-C5252 Cynomolgus CD47 Protein, Fc Tag
CD7-H52A5 Human CD47 Protein, mouse IgG2a Fc Tag, low endotoxin
CD7-M5251 Mouse CD47 Protein, Fc Tag
B7-H3
B73-H5253 Human B7-H3 / CD276 Protein, Fc Tag
B73-H52E2 Human B7-H3 / CD276 Protein
B73-M5255 Mouse B7-H3 / CD276 Protein, Fc Tag
Galectin-9
LG9-H5244 Human Galectin-9 / LGALS9 Protein

 

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